Saliva is an oral fluid that has been described as an "ultra-filtrate of plasma". Saliva has recently been well established as a drug diagnostic tool in detecting many of the molecules that are found in plasma, and at levels equivalent to those found in blood. Therefore, by saliva drug testing, one can obtain similar information on the status of a person as one can obtain from whole blood, without the need to collect a specimen invasively.
Saliva had long been regarded as one of the prodigal children of biological specimens. However, for the past two decades, there has been a steadily increasing interest in the use of saliva in pharmacokinetic studies of drugs in general and in therapeutic drug monitoring in a variety of clinical situations. In more recent years this interest has extended to the measurement of drugs of abuse and alcohol in saliva. The advantages of saliva as the specimen of choice have been identified by psychiatrists studying methadone treatment, investigators involved in therapy for HIV-infected patients and in anticonvulsant treatment for epileptics, and by laboratory directors involved in drug abuse monitoring. Among the advantages cited are the following:
Patients are spared the discomfort of repeated vein punctures
No risk of anemia, infection, or thrombosis
No special staff training for collection, lower total costs
Repeated monitoring of drug levels leads to more accurate prescriptions and fewer side effects
Important: Perhaps, some of end users had taken some kind of food or fluid, which might make the saliva fluid moreviscous. Therefore, the migration of saliva is difficult as a result. We are advising not to take any food or viscous fluid that might cause a problems.
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